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- W2354470147 abstract "Firstly,we sum up some key issues on the occurrence,the development,the invasion and the metastasis research of epithelial tumors,and the way of the expression of COX-2 and zinc finger transcription factor Snail protein in the development of epithelial tumors and its regulatory aspects.Then the paper preliminarily explores the signal significance of cyclooxygenase-signaling pathway(COX-PGEs-dependent pathway) in epithelial ovarian cancer invasion and metastasis:the high expression of COX-2 in the occurrence and development of ovarian cancer can lead to increased levels of prostaglandin E,consequently increasing the zinc-finger transcription factor Snail protein expression,while the binding of Snail protein and E-cadherin promoter effect on the E-Box element inhibits E-cadherin transcription,because E-cadherin reduction as a cell adhesion molecule may promote tumor cell invasion and metastasis potential.Lastly the paper reviews the COX-signal channels and invasive behavior of malignant tumor cells,the mechanism of influence,and the zinc-finger transcription factor Snail as the invasive and metastatic potential of ovarian cancer marker protein." @default.
- W2354470147 created "2016-06-24" @default.
- W2354470147 creator A5049477911 @default.
- W2354470147 date "2010-01-01" @default.
- W2354470147 modified "2023-09-26" @default.
- W2354470147 title "The Relevance Between COX-signaling Pathway and Ovarian Cancer Invasion as well as Metastasis" @default.
- W2354470147 hasPublicationYear "2010" @default.
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