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- W2354473733 abstract "objective To establish a molecular platform for screening thalidomide derivatives with potential high anti-tumor activities. Methods Human cereblon(CRBN) and Ikaros family zinc finger protein 1(IKZF1) c DNA were amplified and cloned into p XJ40-myc and pc DNA3-FLAG vectors respectively. Then the two constructs were transfected into 293 T cells and the anti-tumor activities of thalidomide and its derivatives were reflected by their effects on the binding between CRBN and IKZF1 proteins. Results Both CRBN and IKZF1 were successfully expressed in 293 T cells. Thalidomide and two of its derivatives were found to enhance the interaction between CRBN and IKZF1 significantly. Conclusion A molecular platform was successfully established for screening thalidomide derivatives with potential high anti-tumor activities and two thalidomide derivatives could potentiate the binding between CRBN and IKZF1,suggesting that they possess potential anti-tumor activities." @default.
- W2354473733 created "2016-06-24" @default.
- W2354473733 creator A5025198777 @default.
- W2354473733 date "2015-01-01" @default.
- W2354473733 modified "2023-09-27" @default.
- W2354473733 title "Establishment of a molecular platform for screening thalidomide derivatives with potential high anti-tumor activities" @default.
- W2354473733 hasPublicationYear "2015" @default.
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