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- W2354497799 abstract "OBJECTIVE To evaluate and compare the antiendotoxin activity of five different chemical fractions isolated from Radix Isa-tidis. METHODS By means of kinetic turbidimetric assay, the bacterial endotoxin content in the testing samples was determined. The protection for the mice sensitized by D-galactosamine from endotoxin-induced lethality was investigated.The changes of rectal temperature were observed in feverous rabbits induced by endotoxin. RESULTS Upon the neutral effect of fraction Ⅳ from Radix Isatidis, endotoxin was degraded by 70 % in vivo. Meanwhile, the rates of pyrogenicity and lethality induced by endotoxin respectively were decreased to 32.3 % and 33 % . CONCLUSION Fraction Ⅳ can neutralise endotoxin directly, and inhibit pyrogenicity and lethality induced by endotoxin.Fraction Ⅳ from Radix Isatidis is shown to have remarkable anti-endotoxin activity in vitro and in vivo." @default.
- W2354497799 created "2016-06-24" @default.
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- W2354497799 date "2005-01-01" @default.
- W2354497799 modified "2023-09-28" @default.
- W2354497799 title "Study on chemical fraction with anti-endotoxin activity from Radix Isatidis" @default.
- W2354497799 hasPublicationYear "2005" @default.
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