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- W2354531566 abstract "S-phase kinase associated protein 2(Skp2) is the substrate-recognition domain of the ubiquitin ligase and plays essential roles in regulation of the normal cell cycle.In most malignant tumor cells,Skp2 is always overexpressed and accelerates the G_(1)to S phase progression through ubiquitin/proteasome-dependent degradation of p27~(kip1),one important cyclin-dependent-kinase inhibitory protein.Skp2 has the oncogenic potential,and it tightly correlates with some biologic properties of tumors such as proliferation,differentiation and resistance to induced apoptosis and drug therapy.Skp2 can be used as a dependent prognostic marker.Furthermore,the reserch on Skp2 as a novel target for drug and gene thrapy has been progressed." @default.
- W2354531566 created "2016-06-24" @default.
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- W2354531566 date "2006-01-01" @default.
- W2354531566 modified "2023-09-24" @default.
- W2354531566 title "Effects of Skp2 on the biologic properties of tumors and its use as a prognostic marker and a theraputic target" @default.
- W2354531566 hasPublicationYear "2006" @default.
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