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- W2354538412 abstract "Objective To study the changes of interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α)in peripheral blood(PB) of patients with chronic aplastic anemia(cAA) treated with immune cells mainly composed of dendritic cells(DC).Methods The expression of intracellular IFN-γ and TNF-α in PB CD3+ and CD8+ T cells of 14 normal controls were detect by flow cytometry,and the expression of plasma IFN-γ and TNF-α was measured with ELISA.Fourteen primary patients with cAA were treated with immune cells mainly composed of DC for 10 months.The expression of IFN-γ and TNF-α in PB CD3+ and CD8+ T cells was detect by flow cytometry and their levels in peripheral blood plasma were measuered by ELISA before and 10 months after treatment.Results Elevated levels of IFN-γ and TNF-α were found in blood plasma and CD3+ and CD8+ T lymphocytes of AA patients compared to normal controls(P0.05).After 10 months,there was a significant decline in plasma IFN-γ and TNF-α,intracellular IFN-γ,TNF-α in CD3+ and CD8+ T cells in PB compared to those before treatment(P0.05);there were no significant differences of these cytokines compared to normal controls(P0.05).Conclusion Immune cells therapy may induce hematological remission by suppressing the elevated levels of IFN-γ and TNF-α in AA PB CD3+ and CD8+ T cells and plasma." @default.
- W2354538412 created "2016-06-24" @default.
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- W2354538412 date "2009-01-01" @default.
- W2354538412 modified "2023-09-26" @default.
- W2354538412 title "Effect of immune cells mainly composed of dendritic cells on peripheral blood levels of IFN-γ and TNF-α in patients with chronic aplastic anemia" @default.
- W2354538412 hasPublicationYear "2009" @default.
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