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- W2354539363 abstract "OBJECTIVE To discuss the protein expression of secreted protein acidic and rich in cysteine(SPARC)and matrix metalloproteinase-2(MMP-2)in breast cancer and the relation in clinical pathology.METHODS We used the immunohistochemistry to exam the expression and correlation of SPARC and MMP-2in 70 breast infiltrative ductal carcinoma and 20 fibroadenoma of breast.RESULTS The expression rate of SPARC in breast cancer stromal cell was 68.6%(26/70),much higher than that in tumor cell which was 37.1%(26/70,χ2=13.874,P0.001),which was 40.0%(8/20)in breast fibro adenoma(χ2=5.402,P=0.020).The expression rate of MMP-2in breast cancer tumor cell was64.3%(45/70),much higher than that in stromal cell which was 17.1%(12/70,χ2=32.226,P0.001),which was35.0%(7/20)in breast fibro adenoma of the breast tumor cells(χ2=5.469,P=0.019).The expressions of SPARC and MMP-2in breast cancer tumor cells were related to lymphatic metastasis and TNM staging.Besides,MMP-2had closed connection with HER-2(χ2=12.036,P=0.001).SPARC was positively related to MMP-2(χ2=3.993,P=0.046).CONCLUSIONS The expressions of SPARC and MMP-2in breast cancer tumor cells are highly related to the occurrence,develppment,invasion and metastasis of breast cancer.It may be the reaction between the two factors." @default.
- W2354539363 created "2016-06-24" @default.
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- W2354539363 date "2015-01-01" @default.
- W2354539363 modified "2023-09-24" @default.
- W2354539363 title "Correlation between SPARC and MMP-2 expression in breast cancer tissues" @default.
- W2354539363 hasPublicationYear "2015" @default.
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