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- W2354553310 abstract "Inositol 1,4,5-trisphosphate receptor (IP3R) functions as an intracellular Ca2+ channel. It participates in the pathways of calcium-induced signal transduction and regulations of cellular activity through a change in intracellular Ca2+ concentration when binding to its ligand, inositol 1,4,5-trisphosphate (IP3). In recent years, increasingly researches have shown that IP3Rs played a vital role in the development of some cardiovascular disease, especially in heart failure, myocardial hypertrophy and atrial fibrillation. In this review, the recent advancement in structure and distribution of IP3R, the mechanism it activates Ca2+ channel and its relationship with cardiovascular disease are discussed." @default.
- W2354553310 created "2016-06-24" @default.
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- W2354553310 date "2007-01-01" @default.
- W2354553310 modified "2023-09-24" @default.
- W2354553310 title "The research of inositol 1,4,5-triphosphate receptor and cardiovascular disease" @default.
- W2354553310 hasPublicationYear "2007" @default.
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