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- W2354555650 abstract "Objective To investigate the effect of prescription of pressure sensitive adhesives on the percutaneous absorption of artesunate.Methods Various polyacrylate pressure sensitive adhesive formulations were designed.The effects of various additives on the crystallization of artesunate in polyacrylate adhesive matrix were investigated.Modified Franz mothern method was used to study the effects of various additives and pressure-sensitive adhesives on the permeation of artesunate across SD rat abdominal skin.Results Polymethacrylates Eudragit EPO and Polyvinyl pyrrolidone(PVP-K30)inhibited significantly the crystallization of artesunate in polyacrylate adhesive matrix,and increased the drug loading of artesunate in pressure sensitive adhesives.The addition of Eudragit EPO and PVP-K30 increased the flux of artesunate with the polyacrylate adhesive matrix after a storage period of 6 weeks.ConclusionThese observations indicate that improvement of drug loading in the solubility of artesunate is necessary to fully realize the clinically applicable transdermal delivery system." @default.
- W2354555650 created "2016-06-24" @default.
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- W2354555650 date "2009-01-01" @default.
- W2354555650 modified "2023-09-25" @default.
- W2354555650 title "Studies on the prescription of pressure sensitive adhesives of Artesunate Patch" @default.
- W2354555650 hasPublicationYear "2009" @default.
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