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- W2354557296 abstract "[Objective] To evaluate the role of genetic factor on the occurrence of esophageal cancer and the inheritance pattern of esophageal cancer in Huaian County.[Methods] By population based case-control study,97 patients in Huaian were diagnosed,and 97 healthy controls matched with cases on age,sex,nation and residence were recruited in the case-con-trol study.The inheritance pattern of esophageal cancer was estimated by Li-Mantel-Gart' s method and Penrose's method.Heritability was calculated with Falconer's method.[Results] Statistically significant differences were found in family history of esophageal cancer between probands compared with controls.Significantly increased risk for esophageal cancer was observed in the first degree relatives of esophageal cancer probands.Segregation ratio was 0.026(95%CI:0.0003～0.028) and the heritability of first degree relatives was(24.769±7.038) %.[Conclusion] Family clustering has been proved in esophageal cancer of Huaian population.Genetic factor is significantly related to enhanced risk for esophageal cancer.The inheritance pattern of esophageal cancer belongs to polygenetics mode." @default.
- W2354557296 created "2016-06-24" @default.
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- W2354557296 date "2009-01-01" @default.
- W2354557296 modified "2023-09-27" @default.
- W2354557296 title "GENETIC EPIDEMIOLOGY STUDY ON ESOPHAGEAL CANCER IN HUAIAN COUNTY" @default.
- W2354557296 hasPublicationYear "2009" @default.
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