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- W2354558441 abstract "Objective To examine the expression of TLRs in S180 osteosarcoma cells in vitro and at earlier and advanced stages of tumor-bearing mouse in vivo;To reveal the expression of TGF-β and IL-10 after stimulating the S180 osteosarcoma cells by LPS in vitro;And to explore the mechanisms of tumor tolerance induced by TLRs express in tumor cells.Methods S180 ascites carcinoma models were established.The expression of TLRs mRNA in S180 osteosarcoma cells in vitro,and at earlier and advanced stages of tumor-bearing mouse in vivo as well as the changes of TGF-β and IL-10 after stimulating the S180 osteosarcoma cells by LPS were analyzed by semi-quantitative RT-PCR.The changes of TGF-β protein were detected by ELISA.Results S180 osteosarcoma cells could express TLR1～7 and TLR 9,while couldn’t express TLR8 in vitro.The expression of TLR4 and TLR9 was higher in earlier stage than that in advanced stage.The expression of TLR4 was in significant difference in different stages(P0.05).The express of TLR1,TLR2,TLR3,TLR5,TLR6,and TLR7 was lower in earlier stage than that in advanced stage,while showed no significant difference(P0.05).The expression of TGF-β and IL-10 increased and depended on time after stimulating S180 osteosarcoma cells using LPS at 10μg/ml level.Conclusion S180 in osteosarcoma cells could express many kinds of TLRs,and the TLRs expression changed in different stage.Thus the express of TLRs in S180 osteosarcoma cells played different roles in different stages during the development of tumor.The activation of TLR4 could promote the expression of TGF-β and IL-10,and then enhanced the tolerance of tumor cells." @default.
- W2354558441 created "2016-06-24" @default.
- W2354558441 creator A5042951671 @default.
- W2354558441 date "2010-01-01" @default.
- W2354558441 modified "2023-09-28" @default.
- W2354558441 title "Expression of TLRs in S180 Osteosarcoma and Relationship between TLRs and Tumor Tolerance" @default.
- W2354558441 hasPublicationYear "2010" @default.
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