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- W2354564276 abstract "Objective:To develop a LC-MS/MS method for the determination of the diphenoxylate in human serum and provide proof for the poisoners′ diagnosis.Methods:Diphenoxylate was extracted from serum by acetonitrile which was used as deproteinated solvent,and separated on a Shim-pack XR-ODS column maintained at 35℃ with acetonitrile and 10 mmol/L ammonium acetate as mobile phase by gradient elution.The flow rate was 0.30 ml/min and 5 μl aliquot of residues were injected into the LC-MS/MS system.Detection was carried out by multiple reaction monitoring on a 3200 LC-MS/MS system.Results:The assay was linear over the range 0.1 ng/ml～1000 ng/ml with a limit of quantitation of 0.1 ng/ml and a limit of detection of 0.01 ng/ml.The relative deviation of intra-and inter-day were 2.7%,3.8%.Conclusion:The method is a rapid,sensitive and reliable for the determination of diphenoxylate in human serum blood.The assay is applied to a fast qualitative and quantitative determination of diphenoxylate poisoners." @default.
- W2354564276 created "2016-06-24" @default.
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- W2354564276 date "2010-01-01" @default.
- W2354564276 modified "2023-09-26" @default.
- W2354564276 title "LC-MS/MS determination of diphenoxylate in human blood and application in clinical study" @default.
- W2354564276 hasPublicationYear "2010" @default.
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