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- W2354580003 abstract "AIM:To evaluate the effects of CYP2CI9 and CYP2C9 gene polymorphisms on Val- proate(VPA)clearance of epileptic patients in China in order to promote individualized medicine.METHODS: The demographic data and steady plateau concentrations of VPA from 216 epileptic patients to tetrospectively collect- ed.The gene polymorphisms of CYP2C19 and CYP2C9 were examined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).According to the genotype of CYP2C19 and CYP2C9,these pa- tients were divided into three groups:G1(wild type), G2(heterozygous type),G3(homozygous type).The mean of VPA oral clearance(CL/F)was calculated for each group,and was compared among three groups.The relationship between mean of VPA oral clearance and gene polymorphism was characterized by multiple regression analysis.RESULTS:In 216 cases of Chinese patients, the number of patients in each group was 86(G1),86 (G2)and 44(G3).The mean plateau concentrations in three groups were(54.13±21.53),(54.43±18.86), (62.55±25.62)μg/mL,and CL/F of VPA were (11.49±4.47),(11.13±4.95),(9.40±4.67) mL·h~(-1).kg~(-1),respectively.The CL/F of VPA in G3 group was lower than those in the other two groups.There was significant correlation between genotype and VPA oral clearance.The regression equation were as following:G1 group:Y=7.395+0.299 mg·kg~(-1)·d~(-1),G2 group:Y =4.503+0.473 mg~(-1)·kg~(-1)·d~(-1);G3 group:Y= 5.025+0.335 mg·kg~(-1)·d~(-1).CONCLUSION:The polymorphisms of CYP2C19 and CYP2C9 have effects on the VPA oral clearance.The CL/F of VPA in ho- mozygous type is significantly lowered than one in bet- erozygous type.It will be valuable to facilitate individual- ized usage of VPA according to the genotype in clinical therapy." @default.
- W2354580003 created "2016-06-24" @default.
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- W2354580003 date "2007-01-01" @default.
- W2354580003 modified "2023-09-28" @default.
- W2354580003 title "Effects of CYP2C19 and CYP2C9 genotype on valproate clearance in patients with epilepsy in China" @default.
- W2354580003 hasPublicationYear "2007" @default.
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