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- W2354584146 abstract "Objective To evaluate the insulin secretion and sensitivity in patients with different subtypes of impaired glucose regulation(IGR),and investigate the 2-year outcomes of glucose tolerance.Methods Ninety-two patients with IGR were followed up for 2 years.At baseline and during follow-up,75 g oral glucose tolerance tests(OGTT) were performed.β cell function index of homeostasis model assessment(HOMA-β) and β cell secretion function(BCF) index(first-phase BCF,BCF-Ⅰ;second-phase BCF,BCF-Ⅱ) of homeostasis model assessment were employed to evaluate insulin secretion,insulin resistance index of homeostasis model assessment(HOMA-IR) was adopted to determine hepatic insulin sensitivity,and insulin sensitivity index(ISI) was used to assess peripheral insulin sensitivity.Results According to baseline OGTT findings,92 patients with IGR were divided into isolated-impaired fasting glucose group(I-IFG group,n=16),isolated-impaired glucose tolerance group(I-IGT group,n=66) and complex glucose intolerance group(CGI group,n=10).There was no significant difference in age,gender,overweight/obesity,blood pressure and lipids among groups(P0.05).At baseline,HOMA-IR declined in the order of CGI group,I-IFG group and I-IGT group,ISI increased in the order of CGI group,I-IGT group and I-IFG group,and BCF-Ⅰincreased in the order of I-IFG group,CGI group and I-IGT group,with significant differences among groups(P0.05 for all).During the follow-up for 2 years,20 patients with IGF developed into diabetes mellitus,with the cumulative incidence of 21.7%.Conclusion IGT is the main form of IGR.Impairment of first-phase secretion of β cell is most significant in I-IFG population.CGI population has the most serious hepatic and peripheral insulin resistance.I-IFG population has more serious hepatic insulin resistance than I-IGT population,and that is opposite for peripheral insulin resistance." @default.
- W2354584146 created "2016-06-24" @default.
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- W2354584146 date "2011-01-01" @default.
- W2354584146 modified "2023-09-23" @default.
- W2354584146 title "Clinical features and 2-year outcomes of patients with impaired glucose regulation" @default.
- W2354584146 hasPublicationYear "2011" @default.
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