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- W2354588352 abstract "Objective To explore the relationship between the development of congenital heart disease (CHD) in children and their parents' environmental exposure during pre-gestational and gestational periods in high prevalent district. Methods Face-to-face structured interviews were carried out to mothers with CHD children (subjects) and 1 ∶ 2 case- control study was designed. One hundred and sixty-eight useable questionnaires had been collected including 56 subjects and 112 controls. Conditional logistic stepwise regression was performed to analyze the environmental risk factors during past six months before pregnancy and during gestational periods of parents with CHD children. Results Living in noisy environments during past six months before pregnancy, previous spontaneous abortion, taking hormone and catching a cold during the first trimester and other types of fetal abnormality detected during pregnancy related to the occurrence of CHD (P 0.05, OR = 2.15, 13.16, 69.11, 2.65, 4.07, respectively). Maternal exposure to noisy environments during past six months before pregnancy highly related to the occurrence of atrial septal defect (P 0.05, OR = 5.13). Paternal exposure to heavy metal during past six months before pregnancy and fetal abnormality detected during pregnancy related to the occurrence of ventricular septal defect ( P 0.05, OR = 4.14, 12.48, respectively) . Conclusions Improving parents' health, status or reducing the exposure of environmental risk factors and strengthening pregnant care were thought to be good for reducing development of congenital heart disease." @default.
- W2354588352 created "2016-06-24" @default.
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- W2354588352 date "2009-01-01" @default.
- W2354588352 modified "2023-09-23" @default.
- W2354588352 title "Parental environmental exposure and occurrence of congenital heart disease in their children" @default.
- W2354588352 hasPublicationYear "2009" @default.
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