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- W2354588446 abstract "Objective To study the effects of on left ventricular remodeling in New Zealand rabbit chronic heart failure(CHF) model.MethodsTwenty four New Zealand rabbits were equally divided into 4 groups.To estalish the CHF model,coarctation of obdominal aorta and aortic regurgitation were made by operation on rabbit in group 1-3,rabbit in group 4 received sham operation as control(control group).Rabbits in group 1 received no drugs(CHF control group);rabbit in group 2 recieved simvastatin 5 mg·kg-1·d-1 just after operation(early intervention group);rabbits in group 3 received simvastatin 5 mg·kg-1·d-1 4 weeks after operation(late intervention group).We performed 2D and Doppler echocardiography on all rabbit just post operation at begin and at the end of experiment.Results At the end of observation,the heart weight,left ventricular weight,heart/body weight ratio,left ventricular/body weight ratio,left-ventricular end-diastolic and end-systolic internal diameter(LVIDd and LVIDs),diastolic thickness of the interventricular septum(LVSd),diastolic thickness of the left-ventricular posterior wall(LVPWd),and the apoptotic index(AP)were significantly lower,the EF,FS were significantly higher in rabbits received early treatment of simvastatin and in late treatment rabbits by simvastatin than those in CHF rabbitsConclusionsUse of simvastatin in chronic heart failure rabbit models could inhibit heart enlarge and the development of cardiac hypertrophy and prevent the cardiomyocyte apoptosis and improve left vetriculer remodeling." @default.
- W2354588446 created "2016-06-24" @default.
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- W2354588446 date "2007-01-01" @default.
- W2354588446 modified "2023-09-27" @default.
- W2354588446 title "Effects of simvastatin on left ventricular remodeling in rabbit with chronic heart failure" @default.
- W2354588446 hasPublicationYear "2007" @default.
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