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- W2354600673 abstract "Objective: To study the effect of acupuncture Yongquan point on gene expression in aging rat model induced by D galactose using cDNA microarrays. Methods: Rats were divided to the model group and the acupuncture group at random. Aging model were made by subcutaneous injection of D galactose. The model rats in the acupuncture group were treated by acupunctured at Yongquan point every day for 5 times a week. The rats were sacrificed after seven weeks, the liver was taken out to extract mRNA for reverse transcription cDNA. 2305 cDNA were elected to made microarray for analysis. cDNA extracted from model rats were labeled with Cy3 dUTP while cDNA extracted from acupuncture group were labeled with Cy5 dUTP. These probes were hybridized with cDNA microarray, scanned and analyzed. There were 318 differentially expressed in rats of the acupuncture group, 137 were up regulated and 181 were down regulated. Priliminary analysis was made on 55 cDNA with most significant difference. Results: Acupuncture has vast effects on aging rats′ gene expression, involving multiple scopes as immunity, growth and development, basal metabolism and cell skeleton motion. Acupuncture is proved, on gene level, to have a holistic regulation. Conclusion: The state of thousands gene expression could be studied simultaneously by cDNA microarray semiquantitatively, through which the holistic mechanism of acupuncture could be investigated on microcosmic gene level to evaluate its molecular effect, so as to raise the level of TCM research." @default.
- W2354600673 created "2016-06-24" @default.
- W2354600673 creator A5070109882 @default.
- W2354600673 date "2002-01-01" @default.
- W2354600673 modified "2023-09-23" @default.
- W2354600673 title "Preliminary Analysis of 318 Differentially Expressed Genes Screened out by cDNA Microarray of Aging Rat Model Treated by Acupunctured at Yongquan Point" @default.
- W2354600673 hasPublicationYear "2002" @default.
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