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- W2354607530 abstract "Objective To evaluate the feasibility and efficiency of adenovirus mediated P21 gene transfer to local artery by protein coated nitinol stent.Materials and Methods Four experimental canine models with iliac artery stenosis were used in this study. Gelatin coated nitinol stents was immersed into the adenovirus mediated P21 gene stock for 5 minutes, then implanted into one iliac artery of the experimental model by 7F catheter scabbard. And gelatin coated stent having not been prepared with P21 gene immersion was implanted into the other iliac artery of the same animal as control. All 4 animals were sacrificed 7 days after the procedure. External P21 expression was assessed with RT PCR and immunohistochemistry staining.Results The expression of P21 was detected in the intimal, media and adventitia of all transgenic arteries by RT PCR and immunohistochemistry, while no positive expression was found in the controls.Conclusion Adenovirus mediated P21 gene transfer to endothelial, smooth muscle cell and adventitia is feasible and efficacious by using protein coated nitinol stent, which may be an effective means for the gene therapy of restenosis due to PTA." @default.
- W2354607530 created "2016-06-24" @default.
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- W2354607530 date "2002-01-01" @default.
- W2354607530 modified "2023-09-25" @default.
- W2354607530 title "Adenovirus-mediated P21 Gene Transfer to Local Artery by Protein-coated Nitinol Stent" @default.
- W2354607530 hasPublicationYear "2002" @default.
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