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- W2354627859 abstract "Objective To investigate the serum levels of adiponectin(APN), interleukin-6(IL-6), high sensitivity C-reactive protein(hs-CRP) and their correlation in patients of type 2 diabetes mellitus(T2DM) with coronary heart disease(CHD). Methods Eighty T2 DM patients were divided into two groups: 40 patients with CHD(group C) and 40 patients without CHD(group B). Forty healthy subjects were enrolled as the control people(group A). The levels of APN, IL-6 and hs-CRP in these three groups were measured by ELISA assay, and the level of glycosylated hemoglobin A1c(GHb A1c) was routinely detected. Pearson correlation analysis was used to analyze the correlation between the three indexes. Results IL-6 and hs-CRP levels in group C were significantly higher than those in group B and group A(P0.05), while APN level in group C was significantly lower compared with group B and group A(P0.05). According to correlation analysis, serum hs-CRP level was positively correlated with IL-6(r=0.725, P0.05),with serum GHb A1 cpositively correlated with hs-CRP and IL-6(r=0.873, 0.912, P0.01), while serum APN level was negatively correlated with hs-CRP and IL-6 in group C(r=-0.816,-0.79, P0.01). Conclusion APN is an antiatherogenic factor for atheromatosis, while IL-6 and hs-CRP are inflammatory factors resulting in atheromatosis. These three factors all participate in the pathogenesis and progression of atherosclerosis in T2 DM patients with CHD. Early intervention for these inflammatory factors level can effectively delay the development of CHD in T2 DM patients." @default.
- W2354627859 created "2016-06-24" @default.
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- W2354627859 date "2015-01-01" @default.
- W2354627859 modified "2023-09-23" @default.
- W2354627859 title "Serum levels of adiponectin, interleukin-6, high sensitivity C-reactive protein and their correlation in type 2 diabetic patients with coronary heart disease" @default.
- W2354627859 hasPublicationYear "2015" @default.
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