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- W2354654350 abstract "By using rat testicular germ cells bioassays in vitro based on original cells culture, the reproductive toxicity of different polar organic extracts from drinking source water was evaluated. Five bioassays in vitro (cells morphologic changes, proliferation activity, lactic dehydrogenase activity, the percentage of apoptotic and necrotic cells and testosterone secretion)were utilized to detect the reproductive toxicity. Results showed that organic extracts of drinking source water from X city and L city could induce significant cell shrinkage on sertoli cells and leydig cells, and the damage of spermatogenic cell was the most severe. The influence of the organic extract from X city on LDH activity in 3 kinds testicular cells was not significant (p0.05), however, exposed to the organic extracts from L city, the LDH activity of sertoli cells and leydig cells increased significantly (p0.01). Exposed to the organic extracts from X city, the testosterone secretion of leydig cells decreased significantly(p0.01), however, the influence of the organic extract from L city on the testosterone secretion of leydig cells was not significant (p0.05). The results of present study indicated that the organic extracts of drinking source water from X city and L city could induce the reproductive toxicity on rat testicular germ cells, and spermatogenic cells might be the most sensitive to environmental harmful agents, these reproductive bioassays in vitro could be useful for the assessment of drinking source water quality." @default.
- W2354654350 created "2016-06-24" @default.
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- W2354654350 date "2009-01-01" @default.
- W2354654350 modified "2023-09-28" @default.
- W2354654350 title "Reproductive Toxicity of Drinking Source Water and Selection of Sensitive Bioassays" @default.
- W2354654350 hasPublicationYear "2009" @default.
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