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- W2354654412 abstract "OBJECTIVE To develop a reversed-phase high performance liquid chromatographic(RP-HPLC) method for the determination of four cytochrome P450 in rat plasma.METHODS The four specific probe substrates of caffeine,dapsone,phenytoin and chlorzoxazone,together with the internal standard antipyrine,were extracted using liquid liquid extraction in rat plasma,followed by RP-HPLC using a Dikma Diamonsil-C18(4.6 mm×200 mm,5.0 μm).The mobile phase consisted of a methanol and 0.02 mol·L-1 potassium dihydrogephosphate buffer solution(48∶52,adjusted to pH 6.5 with phosphate).All analytes were separated simultaneously in a single run.RESULTS The linear concentration ranges of the calibration curves for caffeine,dapsone,phenytoin and chlorzoxazone were 0.2-1.6,0.075-0.600,0.2-1.6 and 0.25-2.00 mg·L-1,respectively.The intra-day and inter-day relative standard deviations(RSD) were less than 5.14%.The methodological recoveries of the four probes were more than 95.0%(RSD6.14%).CONCLUSION The RP-HPLC method is rapid,sensitive,precise and selective,and can be suitable for determining the plasma concentration of these probes and evaluating the CYP1A2,CYP3A4,CYP2C9 and CYP2E1 activities in the rats." @default.
- W2354654412 created "2016-06-24" @default.
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- W2354654412 date "2010-01-01" @default.
- W2354654412 modified "2023-09-23" @default.
- W2354654412 title "Determination of Four Cytochrome P450 Probe Drugs by RP-HPLC in a Single Run" @default.
- W2354654412 hasPublicationYear "2010" @default.
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