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- W2354665280 abstract "Objective:Biological films with sustained release drug were prepared and applied to glaucoma therapy with operation.Method:The triamcinolone acetonide (TA) was used as a model drug,and the biological membranes with chitosan and gelatin as carriers were prepared through solvent volatilization.Then their structures and composing were analyzed by Fourier transform infrared spectroscopy (FT-IR),X-ray diffraction (X-RD),scanning dectron microscopy (SEAM).After it had been implanted under the scleral lamella of New Zealand albino rabbits' eyes,its effects were observed.Results:There was a good compatibility between the drug and carriers in membranes.The drug was loaded in the film in crystallite with full functions of drug activity.There was also a good biocompatibility between the films and ocular tissues in rabbit eyes.Besides,sustained release drug could effectivdy restrain fibrin hyperplasia and cicatrisation.Because of perfect and filterable configuration of decompression cham- ber under conjunctiva and sderal lamella after 8 weeks,ophthalmotonus could maintain in the perfect level.Conclusion:The cu- rative effect with this film used in the operation of glaucoma was superior to the traditional method.Gonsequenfly,it could be a safe and effective new method to treat glaucoma." @default.
- W2354665280 created "2016-06-24" @default.
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- W2354665280 date "2007-01-01" @default.
- W2354665280 modified "2023-09-25" @default.
- W2354665280 title "Preparation of Biological Delivery Films and the Study on its Application in Glaucoma Therapy" @default.
- W2354665280 hasPublicationYear "2007" @default.
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