Matches in SemOpenAlex for { <https://semopenalex.org/work/W2354666437> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2354666437 abstract "Objective:To investigate the role of human endostatin(hES) on ovarian cancer cells A2780 growth in vitro and in vivo.Methods:The coding region for human endostatin(hES) was amplified by PCR from human liver tissue and then following subcloning into pCDNA3.1 vector.To observe the growth rate of A2780 cells after hES transfected.A2780 cells were inoculated subcutaneously into 20 nude mice,which were randomly divided into the hES transfected group(group A,n=10) and the control group(group B,n=10).The tumor weights of subcutaneous tumor were detected.And the tumor inhibition rate were calculated.The histological analysis was used by HE stain.Cell apoptosis in ovarian neoplasm transplantation cells were determined by flow cytometry.The expressions of human endostatin,apoptosis-related protein bcl-2 were analyzed by Western blot.Results:The growth rates of the hES transfected ovarian cancer cells A2780 were significantly decreased.In group A,the tumor inhibition rate was 74%.The hES transfected ovarian cancer cells A2780 was able to inhibit ovarian cancer growth in nude mice.The histological shape between group A and group B had a significant difference.The expressions of human endostatin in group A was higher than that of group B.And bcl-2 in group A was lower than that of group B.There was significant difference of apoptosis rate between group A and group B(P0.05).Conclusion:hES can decrease ovarian cancer cells A2780 growth in vitro and in vivo and its mechanism may be due to apoptosis promotion." @default.
- W2354666437 created "2016-06-24" @default.
- W2354666437 creator A5002115485 @default.
- W2354666437 date "2009-01-01" @default.
- W2354666437 modified "2023-09-25" @default.
- W2354666437 title "The effect of human endostatin on the growth of ovarian cancer cells A2780 growth in vitro and in vivo" @default.
- W2354666437 hasPublicationYear "2009" @default.
- W2354666437 type Work @default.
- W2354666437 sameAs 2354666437 @default.
- W2354666437 citedByCount "0" @default.
- W2354666437 crossrefType "journal-article" @default.
- W2354666437 hasAuthorship W2354666437A5002115485 @default.
- W2354666437 hasConcept C121608353 @default.
- W2354666437 hasConcept C126322002 @default.
- W2354666437 hasConcept C150903083 @default.
- W2354666437 hasConcept C153911025 @default.
- W2354666437 hasConcept C16685009 @default.
- W2354666437 hasConcept C190283241 @default.
- W2354666437 hasConcept C202751555 @default.
- W2354666437 hasConcept C203014093 @default.
- W2354666437 hasConcept C207001950 @default.
- W2354666437 hasConcept C2780394083 @default.
- W2354666437 hasConcept C2780427987 @default.
- W2354666437 hasConcept C502942594 @default.
- W2354666437 hasConcept C54009773 @default.
- W2354666437 hasConcept C54355233 @default.
- W2354666437 hasConcept C553184892 @default.
- W2354666437 hasConcept C55493867 @default.
- W2354666437 hasConcept C62112901 @default.
- W2354666437 hasConcept C71924100 @default.
- W2354666437 hasConcept C75920679 @default.
- W2354666437 hasConcept C81885089 @default.
- W2354666437 hasConcept C86803240 @default.
- W2354666437 hasConceptScore W2354666437C121608353 @default.
- W2354666437 hasConceptScore W2354666437C126322002 @default.
- W2354666437 hasConceptScore W2354666437C150903083 @default.
- W2354666437 hasConceptScore W2354666437C153911025 @default.
- W2354666437 hasConceptScore W2354666437C16685009 @default.
- W2354666437 hasConceptScore W2354666437C190283241 @default.
- W2354666437 hasConceptScore W2354666437C202751555 @default.
- W2354666437 hasConceptScore W2354666437C203014093 @default.
- W2354666437 hasConceptScore W2354666437C207001950 @default.
- W2354666437 hasConceptScore W2354666437C2780394083 @default.
- W2354666437 hasConceptScore W2354666437C2780427987 @default.
- W2354666437 hasConceptScore W2354666437C502942594 @default.
- W2354666437 hasConceptScore W2354666437C54009773 @default.
- W2354666437 hasConceptScore W2354666437C54355233 @default.
- W2354666437 hasConceptScore W2354666437C553184892 @default.
- W2354666437 hasConceptScore W2354666437C55493867 @default.
- W2354666437 hasConceptScore W2354666437C62112901 @default.
- W2354666437 hasConceptScore W2354666437C71924100 @default.
- W2354666437 hasConceptScore W2354666437C75920679 @default.
- W2354666437 hasConceptScore W2354666437C81885089 @default.
- W2354666437 hasConceptScore W2354666437C86803240 @default.
- W2354666437 hasLocation W23546664371 @default.
- W2354666437 hasOpenAccess W2354666437 @default.
- W2354666437 hasPrimaryLocation W23546664371 @default.
- W2354666437 hasRelatedWork W2118253705 @default.
- W2354666437 hasRelatedWork W2347572018 @default.
- W2354666437 hasRelatedWork W2348413630 @default.
- W2354666437 hasRelatedWork W2349082373 @default.
- W2354666437 hasRelatedWork W2352753912 @default.
- W2354666437 hasRelatedWork W2353433328 @default.
- W2354666437 hasRelatedWork W2355633081 @default.
- W2354666437 hasRelatedWork W2372743597 @default.
- W2354666437 hasRelatedWork W2375481860 @default.
- W2354666437 hasRelatedWork W2378797806 @default.
- W2354666437 hasRelatedWork W2380716314 @default.
- W2354666437 hasRelatedWork W2387459698 @default.
- W2354666437 hasRelatedWork W2391535568 @default.
- W2354666437 hasRelatedWork W2414734378 @default.
- W2354666437 hasRelatedWork W2518682401 @default.
- W2354666437 hasRelatedWork W3030874370 @default.
- W2354666437 hasRelatedWork W3032310931 @default.
- W2354666437 hasRelatedWork W3032674880 @default.
- W2354666437 hasRelatedWork W3173173441 @default.
- W2354666437 hasRelatedWork W1817508758 @default.
- W2354666437 isParatext "false" @default.
- W2354666437 isRetracted "false" @default.
- W2354666437 magId "2354666437" @default.
- W2354666437 workType "article" @default.