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- W235469835 abstract "Chlamydia pneumoniae has been associated with cardiovascular disease and stroke in humans by numerous cross-sectional and case–control studies, but prospective, longitudinal studies have produced mixed results and most have not confirmed this association. However, pathological studies have established the association of C. pneumoniae antigen or DNA with atherosclerosis from surgical and autopsy vascular specimens, with odds ratio of around 20. Although in vitro and cell culture studies have supported biological plausible mechanisms for C. pneumoniae to induce or accelerate atherosclerosis, they lack the complexity of a real disease, thus limiting the scope of testing the hypothesis of causality. Animal models are more likely to mimic real disease in humans, and are critical in many conditions in the understanding of the pathogenesis, cause-andeffect relationships and subsequent approaches to treatment and prevention of diseases. Thus, animal experimentation in medical research has played a major role in our understanding of diseases. The earliest recorded use of animal models extends as far back as 500 BC, when Alcmaeon of Croton defined the function of the optic nerve by transection in a living animal. The Hippocratic treatise on the heart (circa 350 BC) discussed cutting the throat of a pig that drank colored water to study the act of swallowing." @default.
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- W235469835 date "2006-01-27" @default.
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- W235469835 title "Animal Models of Chlamydia pneumoniae Infection and Atherosclerosis" @default.
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- W235469835 doi "https://doi.org/10.1007/0-306-48741-1_11" @default.
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