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- W2354709898 abstract "The mRNA and protein levels of p53, bax, bcl-2 were analyzed in livers using a real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) assay and immunohistochemistry method, respectively.Our results showed that mRNA levels of p53 and bax were increased in a dose-dependent manner and at the SO_2 concentrations of 28.00 and 56.00 mg/m~3 their increases were significant, while mRNA levels of bcl-2 were decreased significantly in livers of rats exposed to SO_2.Dose-dependent increases of p53 and bax proteins in the livers were observed after SO_2 inhalation, while decrease of bcl-2 protein levels was obtained using immunohistochemistry method.These results lead to a conclusion that exposure SO_2 can change the expression of apoptosis-related genes, and it suggests that SO_2 can induce apoptosis in liver of rat and may be related with some apoptosis-related diseases.Elucidating the expression patterns of those factors after SO_2 inhalation might be critical to our understanding mechanisms of SO_2 toxicity and helpful for the therapeutic intervention." @default.
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- W2354709898 date "2006-01-01" @default.
- W2354709898 modified "2023-09-25" @default.
- W2354709898 title "Expression of p53,bax and bcl-2 in Livers from Rats Exposed to Sulfur Dioxide" @default.
- W2354709898 hasPublicationYear "2006" @default.
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