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- W2354743378 abstract "To observe the pharmacological effects and clinic efficacy of Bacillus coagulans(BC_1) tablets on the constipation.Methods Sixty Kunming mice were randomly divided into six groups (each group n=10): blank control,model control,positive drug control(BC_2 tablets) and BC_1 tablets(three doses) groups.BC_1 and BC_2 tablets treated groups in mice received orally BC_2 tablets and BC_1 tablets,the blank control as well as model control groups in mice received orally clean water,once daily for 7days,respectively.Then,all treated groups in mice were administrated orally compound diphenoxylate(CDX) tablets 12 h after fasting the induction of constipation except for blank control group.In clinic trial,eligible thirty-eight patients with chronic constipation in adults were randomly allocated to two groups.There were 20 patients in the BC_1 tablets treated group and 18 patients in the golden Bifidobacterium(GB) tablets controlled group.Two groups in patients were received orally BC_1 tablets or golden bifidobacterium tablets,three times daily for 14~21 days,respectively.Administration of these probiotic preparations was randomized,double blind and double dummy in clinic trial.Results BC_1 tablets could obviously decrease(P0.05) first defecation time,BC_1 tablets and BC_2 tablets all could significantly increase the stool grain number and stool weight in mice with constipation,there were significant difference(P0.05) in those results of the BC_1 tablets and BC_2 tablets comparing to model control group,however,no significant difference(P0.05) between the BC_1 tablets and BC_2 tablets.In clinic trial,the results showed that the cure effectiveness rate of BC_1 tablets was 45.0%and total effectiveness rate was 70.0%,while the corresponding rate of GB tablets was 44.0% and was 72.0% in chronic constipation in adults,respectively.Moreover, no adverse reactions or side effect were found in either drug.Conclusion BC_1 tablets all had obvious pharmacological effects or therapeutic effects on the experimental constipation in mice or the chronic constipation in adults,and no adverse reactions or side effects were found in clinic trial." @default.
- W2354743378 created "2016-06-24" @default.
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- W2354743378 date "2006-01-01" @default.
- W2354743378 modified "2023-09-26" @default.
- W2354743378 title "The experimental study and clinic efficacy of Bacillus coagulans tablets in the treatment of constipation" @default.
- W2354743378 hasPublicationYear "2006" @default.
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