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- W2354754655 abstract "Objective To investigate the changes of apoptosis and caspase 3 activity, left ventricular ejection function, and regional myocardial dysfunction following acute ischemia in dogs. Methods Thirty dogs were divided into experiment and control groups. Dogs in experiment group were studied at 10, 30 or 60 min following left anterior descending coronary artery were occluded. Triphenyltetrazolium chlorde (TTC) staining was used to identify ischemia myocardial. The left ventricular ejection fraction and the degree of the increase in left ventricular wall thickness were detected by echocardiography. The percentage of apoptosis in regional left myocardial dysfunction was detected by terminal deoxynucleotidyl transferease-mediated biotinylated deoxyuridine triphosphate nick end labeling (TUNEL). Caspase 3 activity assay was employed to detect caspase 3 activity. Results Anterior wall of left ventricule and regional interventricular septum in experiment group were ischemic. The degree of the increase in left ventricular wall thickness in experiment group decreased at 10 min after coronary artery occlusion (P0.05). The left ventricular ejection fraction in experiment group had no change at 10 min after coronary artery occlusion. The left ventricular ejection fraction and the degree of the increase in left ventricular wall thickness decreased at 30 min after coronary artery occlusion in experiment group. The positive cells of TUNEL detected in infarcted myocardial had no difference between experiment and control groups at 10 min, and increased in experiment groups at 30 min after coronary artery occlusion (P0.01), caspase 3 activity in experiment group increased at 10min, and reached its peak at 30, 60min after coronary artery occlusion. Conclusion Caspase 3 activated and cell apoptosis may be the early pathologic changes following acute ischemia in dogs, which are related to the left decrease in left ventricular ejection fraction and in left ventricular wall systolic thichness." @default.
- W2354754655 created "2016-06-24" @default.
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- W2354754655 date "2006-01-01" @default.
- W2354754655 modified "2023-09-25" @default.
- W2354754655 title "Changes of cell apoptosis, caspase 3 activity, left ventricular function in experimental acute myocardial ischemia dogs" @default.
- W2354754655 hasPublicationYear "2006" @default.
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