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- W2354785969 abstract "Objective To explore the incidence and risk factors of brain injury in preterm infants and provide basic data for prevention of brain injury and improvement of outcome in preterm infants.Methods Data were collected retrospectively among neonates with gestational age of 37 weeks,who were admitted to NICU in St.Louis Children's Hospital in Washington University School of Medicine from Jan.2005 to Dec.2006.Intraventricular haemorrhage(IVH)and periventricular leukomalacia(PVL)rates were calculated by gestational age.Binary Logistic regression was adopted to identify risk factors associated with brain injury in preterm infants.Results The incidence of IVH and PVL in total preterm population was 17.7% and 4.9%,respectively,while 14.4% and 4.5% in survival preterm infants,48.1% and 14.8% in group at gestational age of 23 to less 25 weeks,35.2% and 11.2% at 25 to less 28 weeks,13.8% and 3.1% at 28 to less 33 weeks,2.8% and 1.7% at 33 to less 37 weeks.Neonatal necrotizing enterocolitis,patent ductus arterious(PDA),and mechanical ventilation(MV)were risk factors in IVH development,while larger gestational age and higher 5-min Apgar scores were protective factors.IVH,MV and maternal perinatal infection were risk factors in PVL,birth weight and female were protective factors.IVH was associated with increased mortality in preterm infants.Conclusions The incidence of brain injury is negatively related to gestational age.Perinatal infection,hypoxia,and the factors influencing cerebral blood dynamics such as PDA and mechanical ventilation are all associated with increased risk of brain injury in premature infants." @default.
- W2354785969 created "2016-06-24" @default.
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- W2354785969 date "2011-01-01" @default.
- W2354785969 modified "2023-09-23" @default.
- W2354785969 title "Incidence and Risk Factors of Brain Injury in Preterm Infants" @default.
- W2354785969 hasPublicationYear "2011" @default.
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