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- W2354804524 abstract "Bovine Viral Diarrhea Virus(BVDV) is an economically important cattle pathogen with a worldwide distribution. Infection with BVDV may result in a wide spectrum of clinical symptoms, including bovine viral diarrhea (BVD), mucosal disease(MD), persistent infection(PI) and immunotolerant, reproductive failure, thrombocytopenia and hemorrhagic syndrome; And their corresponding pathogenesis are also very complicated. PI is crucial for the maintenance of BVDV in cattles. It is caused by infection of pregnant animals with the noncytopathogenic(NCP) BVDV through foetus during the first trimester of pregnancy. It has been shown previously that foetal infection with cytopathogenic(CP) BVDV does not result in persistent infection. MD is the most serious clinical type of BVDV infections. MD has been viewed as the result of persistent infection.It has been documented that super infection of persistently infected animals with an antigenically similar or homologous cpBVDV results in fatal MD, and the sources of the cpBVDV can be generalized from five pionts: ①Insertions of cellular sequences; ②Viral genomic rearrangement and duplications; ③Insertions of cellular sequences,accompaning the viral genomic rearrangement and duplications; ④Defective interference(DI); ⑤The piont mutation. Infection with BVDV can reduce fertility in dairy cow. The mechanism of reproductive disorders have two respects:During the infection with BVDV, ①the quality of the oocytes are impaired; ②the gonadal steroidogenesis encounter disruption, resulting in the disorder of estradiol and progesterone secretion. Thrombocytopenia and hemorrhagic syndrome are two important symptom of BVDV infection. We can classify the mechanism of thrombocytopenia into two ways: ①The platelets in the peripheral circulation were destructed because of the BVDV infection, platelets that have been recently released into the bloodstream from the bone marrow are larger, and therefore mean platelet latelet volume is increased at this situation. ②Thrombocytopenia is attributable to decreased marrow production, older platelets are smaller, and therefore mean plateletlatelet volume is decreased." @default.
- W2354804524 created "2016-06-24" @default.
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- W2354804524 date "2002-01-01" @default.
- W2354804524 modified "2023-09-25" @default.
- W2354804524 title "The Advance in Pathogenesis of Bovine Viral Diarrhea Virus" @default.
- W2354804524 hasPublicationYear "2002" @default.
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