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- W2354806271 abstract "AIM:To investigate the effects of edaravone (ED),a novel free radical scavenger,on arte- rial blood gases,some plasma biochemical parameters,and survival rate in rabbits with septic shock.METH- ODS:After treatment with three different doses of ED (1.6,0.8,0.4 mg.kg~(-1)) to rabbits suffered septic shock, changes of arterial blood gases,blood acid-base scale,plasma levels of lactic acid,MDA,Cr and BUN;ac- tivities of LDH,CAT and SOD were determined in four different time phases.The mortality of animals in 24 h was observed.RESULTS:Four hours after septic shock,metabolic acidosis and respiratory alkalosis occurred,the blood levels of lactic acid,BUN and activity of LDH increased significantly but the activity of SOD reduced markedly;with death rate up to 70%.However,following the treatment with different doses of ED,the degrees of the derangement of blood gases and acid-base equilibrium were improved with enhancement of the plasma activities of SOD and CAT and decrease of the plasma levels of LD,MDA and activity of LDH.The death rate in treated groups was signifcantly lower than that of the model group (P＜0.05).CONCLUSION:ED can increase the protection that of organ and tissue against free radical-mediated injury,decrease the secondary damage of reactive oxygen species,and recover the metabolic derangement of septic shock." @default.
- W2354806271 created "2016-06-24" @default.
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- W2354806271 date "2007-01-01" @default.
- W2354806271 modified "2023-09-25" @default.
- W2354806271 title "Therapeutical efficacy of free radical scavenger edaravone on septic shock rabbits" @default.
- W2354806271 hasPublicationYear "2007" @default.
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