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- W2354812744 abstract "Objective To observe the effect of berberine on serum NO level,SOD activity and eNOS expressions of aorta in type 2 diabetic rats induced by high fat diet plus STZ and explore the mechanism underlying protective effect of berberine on endothelial dysfunction.Methods Wistar rats were randomly divided into diabetic,control,diabetic rats treated with berberine(100 mg/kg),and control rats treated with berberine groups.After treatment,intraperitoneal glucose tolerance test(IPGTT)was performed.The serum fasting blood glucose,insulin,total cholesterol and triglyceride levels were tested,and insulin sensitivity index was calculated.The serum NO level and SOD activity were measured.In addition,eNOS protein expression was measured by immunohistochemical methods.Results Berberine significantly decreased fasting blood glucose,total cholesterol,triglyceride levels in diabetic rats.Berberine treatment also improved IPGTT in diabetic rats and enhanced tissue sensitivity to insulin.After berberine treatment,serum NO level and SOD activity were increased.Immunohistochemical results showed that berberine increased eNOS expression in diabetic rats aorta.Conclusions Berberine ameliorates diabetic endothelial dysfunction through decreasing blood glucose,lipid,improving insulin resistant,antioxidant effect and enhancing NO bioavailability." @default.
- W2354812744 created "2016-06-24" @default.
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- W2354812744 date "2010-01-01" @default.
- W2354812744 modified "2023-09-25" @default.
- W2354812744 title "Protective effect of berberine on aortic endothelial dysfunction in diabetic rats" @default.
- W2354812744 hasPublicationYear "2010" @default.
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