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- W2354827324 abstract "The differentiation-related gene Ndr1 (N-Myc downstream regulated) is upregulated during cell differentiation, and repressed by N-myc and c-myc in several tumor cells. The function of NDRG1 in the peripheral nervous system is necessary for axonal survival. The human cDNA encoding NDRG2(371amino acid residues), which is homologous to NDRG1,was cloned. At the amino acid level, the two genes shared 53% identity. Both proteins contained an α/β hydrolase fold as in human lysosomal acid lipase. Based on UniGene cluster searching, the gene for Ndr2 was located at chromosome 14q11.1-11.2. Northern and dot blot analyses showed that the gene was highly expressed in adult brain, very lowly expressed in fetal tissues and almost not detected in the eight human cancer lines. In addition, NDRG2 was highly expressed in adult skeletal muscle and brain. The results suggest that NDRG2 and NDRG1 might display similar or related specific functions in distinct tissues." @default.
- W2354827324 created "2016-06-24" @default.
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- W2354827324 date "2002-01-01" @default.
- W2354827324 modified "2023-09-23" @default.
- W2354827324 title "Cloning and Tissue Expression of the Novel Human Differentiation-related Gene Ndr2" @default.
- W2354827324 hasPublicationYear "2002" @default.
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