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- W2354831739 abstract "Objective To observe the effects of gastrodin on the liver injury induced by vincristine in rat.Methods SD rats were randomly divided into 5 groups: the control group(A),vincristine group(B),small and middle and large dose gastrodin groups(C~E).Except for group A,Vincristine was administered by intraperitoneal injection on alternate days in B~E groups.Then,from 10th day,gastrodin began to be administered also by intraperitoneal injection each afternoon in C~E groups and saline in A~B groups to observe and record the rat′s weight and general condition.After treatment for 1 week,blood from eyes was taken,the contents of serum ALT and AST measured,and AST/ALT counted.The rat livers were fixed by living perfusion using 4% paraformaldehyde,and hepatic tissue was sliced and dyed with HE.The changes of the structure of liver tissue and cells were observed.Results Vincristine could inhibit rat′s weight growth.But after gastrodin treatment for 1 week,the rat′s weight grew with dose-dependence.The result of serum test showed that ALT and AST/ALT were significantly increased in group B compared with group A(P0.05,P0.01).The ALT and AST/ALT were significantly decreased in groups C~E compared with group B(P0.01,P0.01).The morphology result showed that hepatocytes of group A was marshaling,the cell membrane was intact and no cell degeneration or necrosis was observed,and the inflammatory cells were invisible in the slice.But in the slice of group B,hepatocytes had obvious edema and degeneration liking fat vacuolus and necrosis.In slice the inflammatory cells were visible.However,the morphological structure changes of these liver tissue were improved obviously in different dose gastrodin groups compared with group B. ConclusionGastrodin has protective action on vincristine-induced liver injure in rat with dosage-dependence." @default.
- W2354831739 created "2016-06-24" @default.
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- W2354831739 date "2012-01-01" @default.
- W2354831739 modified "2023-09-23" @default.
- W2354831739 title "Protection of gastrodin on vincristine-induced liver injury in rat" @default.
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