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- W2354833329 abstract "Objective To investigate the role of nitric oxide (NO) and tumor necrosis factor-α(TNF-α) in the pathogenesis of asthma. Methods We detected the contents of NO and TNF-α in the plasma of asthmatic patients and in the plasma and lung tissue of guinea-pig asthmatic models. As well, we detected the contents of NO and TNF-α in the plasma and lung tissue of guinea-pig asthmatic models after the treatment of the dexamathasone and L-NAME. NO was detected by chemiluminescence and TNF-α was detected by radioimmunity. Results The contents of NO, TNF-α in the plasma of the asthmatic patients and in the plasma and lung tissue of guinea-pig asthmatic models were significantly increased, compared with the control group(P0.01). These data of guinea-pig asthmatic models in the plasma and lung tissue were significantly decreased after using dexamethasone by inhalation and intraperitoneal injection or L-NAME by intraperitoneal injection(P0.01). Conclusions NO, TNF-α might play an important role in the pathogenesis of asthma, and the formation of NO might be stimulated by TNF-α, L-NAME and dexamethasone might inhibit the formation of TNF-α, so that it might inhibit and release the formation of the NO in the asthma." @default.
- W2354833329 created "2016-06-24" @default.
- W2354833329 creator A5022071263 @default.
- W2354833329 date "2003-01-01" @default.
- W2354833329 modified "2023-09-23" @default.
- W2354833329 title "Role of NO and TNF-α in asthmatic patients and guinea-pig asthmatic models" @default.
- W2354833329 hasPublicationYear "2003" @default.
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