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- W2354834990 abstract "Objective To study the effects of ACTH on the level of calcitonin gene related peptide (CGRP) in the hippocampus, striatum and lumbar enlargement of the spinal cord of rats with chronic pains induced with modified complete Freund's adjuvant. Methods CGRP level in the nervous tissues was determined with radioimmunoassay. ACTH was injected intraperitoneally into the rats. The rat model of chronic pains was established with subdermic injection of modified complete Freund's adjuvant. Adrenalectomy of the rats was performed. Results The level of CGRP in the lumbar enlargement of the spinal cord was significantly increased in the rats with chronic arthritic pains. Intraperitonel injection of ACTH inhibited the increase of CGRP level and adrenalectomy of the rats attenuated the effects of ACTH. Conclusion ACTH inhibits the increase of CGRP in the lumbar enlargement of the spinal cord in the rats with chronic arthritic pains and the adrenal gland may be involved in the mediation of ACTH induced analgesia." @default.
- W2354834990 created "2016-06-24" @default.
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- W2354834990 modified "2023-09-25" @default.
- W2354834990 title "Effects of ACTH on CGRP level in the brain and spinal cord in the rats with adjuvant- induced chronic arthritic pains" @default.
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