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- W2354838325 abstract "Objective To examine the pharmacokinetic properties of solid lipid nanoparticles (SLN) of testosterone. Methods Testosterone was used as model drug, and SLN was prepared by solvent diffusion method. The physicochemical property and pharmacokinetics of SLN were investigated. Results For the prepared SLN, the size of particles was(389.1± 113.6)nm, zeta value was (-29.8±3.2)mV and entrapment efficiency was (42.3±6.4)%. The 0~48 h relative bioavailability was 259.3%. Conclusion SLN of testosterone can increase the bioavailability markedly, reduce side effect of the liver and can be administrated orally." @default.
- W2354838325 created "2016-06-24" @default.
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- W2354838325 date "2008-01-01" @default.
- W2354838325 modified "2023-09-23" @default.
- W2354838325 title "Pharmacokinetics properties of solid lipid nanopartciles of testosterone" @default.
- W2354838325 hasPublicationYear "2008" @default.
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