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- W2354841567 abstract "To explore the roles of mitochondria complex and oxidative stress in the apoptosis of chicken embryonic neurons exposed to MnCl2,the content of ROS and GSH,the activity of mitochondria respiratory chain complex and apoptosis index in neurons cultivated in DMEM with the final concentration of MnCl2 (0,1.5,2.0,2.5mmol/L) for 24h were detected by using the kits.In result,with the increase of the concentration of MnCl2,the activities of mitochondria respiratory chain complexes Ⅰ,Ⅱ,Ⅲ and Ⅳ and the content of GSH decreased.But in 1.5mmol/L MnCl2 environment,the activity of mitochondria respiratory chain complexⅤ decreased,the content of ROS and the apoptosis index increased,and morphological changes of apoptosis were observed in the neurons.These results indicated that MnCl2 could induce the apoptosis of the chicken embryonic neurons which was performed through oxidative stress caused by decreasing the activities of mitochondria respiratory chain complexes." @default.
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- W2354841567 date "2010-01-01" @default.
- W2354841567 modified "2023-09-24" @default.
- W2354841567 title "Roles of mitochondria complex and oxidative stress in the apoptosis of chicken embryonic neurons induced by manganese chloride." @default.
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