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- W2354848191 abstract "Comparative molecular field analysis(CoMFA) was applied to performing a quantitative structureactivity relationship study on a set of substituted indol-2-ones as growth factor receptor inhibitors for PDGFRβ(platelet-derived growth factor receptor) tyrosine kinase inhibition, and a good predictive model was obtained. The relation coefficient (R~2) of non-cross validation for the model established by the study is 0.999, its F value is 1504.715 and the standard deviation(S) is 0.042. Several new compounds were designed andtheir activities predicted by the model. The result showed that the model can be used to quantitatively prognosticate the biological activity of analogues. Moreover, it provides a theoretical foundation for designing and synthesizing new PDGF-Rβ kinase inhibitors." @default.
- W2354848191 created "2016-06-24" @default.
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- W2354848191 date "2004-01-01" @default.
- W2354848191 modified "2023-09-25" @default.
- W2354848191 title "Study on indol-2-ones as PDGF-Rβ kinase inhibitors" @default.
- W2354848191 hasPublicationYear "2004" @default.
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