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- W2354854891 abstract "Objective To investigate the expression of TTF-l(transcription factor1) and MC(mesothelial cell) in the pleural fluid of patients with lung cancer.Methods The expressions of TTF-l and MC were examined by means of S-P immunocytochemical technique in cancer cells of pleural fluid from 35 patients with primary lung cancer and 10 patients with secondary lung cancer,and in reactive mesothelial cells of pleural fluid from 20 patients with benign lung diseases.Results The positive rate of TTF-l in the cancer cells of pleural fluids of patients with primary lung cancer was 74.2%(26/35),but none of the secondary lung cancer and benign lung disease cases expressed TTF-l.The positive rate of MC in reactive mesothelial cells of pleural fluid from benign lung diseases was 95.0%(19/20),which was significantly higher than 22.8%(8/35) of primary lung cancer and 20.0%(2/10) of secondary lung cancer.In different pathologcial types of primary lung cancer,the positive rate of adenocarcinoma was 95.7%(22/23),which was significantly higher than 12.5%(1/8) of squamous cell carcinomas.The optimal assay was the combination of TTF-land MC,whose sensitivity and specificity were 96.7% and 95.5% respectively.Conclusion TTF-1 and MC are clinically valuable for diagnosing and differentially diagnosing the cancer cells in the pleural fluid of patients with primary and secondary lung cancer,meanwhile,the clinical staging of lung cancer has a higher value." @default.
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- W2354854891 date "2011-01-01" @default.
- W2354854891 modified "2023-09-26" @default.
- W2354854891 title "Diagnosis and differential diagnosis value of TTF-1 and Mesothelial Cell in the pleural effusion of lung cancer" @default.
- W2354854891 hasPublicationYear "2011" @default.
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