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- W2354862223 abstract "Objective To study the effects of levofloxacin on the expression of small RNAs in Staphylococcus aureus and its effect on bacterial growth.Methods Two S.aureus lab strains,RN6390 and RN1HG001,were cultured in the presence of different concentrations of levofloxacin.Then RNA was isolated from the bacterial culture.Afterwards,qRT-PCR was used to detect RNAⅢ,RsaA,RsaE,RsaG,and RsaH production.Data analysis compared the changes in expression of the 5 sRNAs in the presence of different concentrations of levofloxacin.Results The MIC of levofloxacin on RN6390 and RN1HG001 in BH medium was identical to that in MH medium(0.25 μg/ml).Among the 5 sRNAs,RNAⅢ was expressed the most while RsaG was expressed the least.A concentration of levofloxacin above 1/4 MIC markedly suppressed the growth of RN6390 and RN1HG001.At a concentration of levofloxacin above 1/4 MIC,the expression of all of the sRNAs started to decrease.The RsaH level in RN6390 increased in the presence of 1/16 MIC or 1/8 MIC levofloxacin.Conclusion Levofloxacin can either promote or suppress sRNA expression depending on its concentration.Apart from its role in blocking DNA replication,it may also affect gene transcription." @default.
- W2354862223 created "2016-06-24" @default.
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- W2354862223 date "2012-01-01" @default.
- W2354862223 modified "2023-09-26" @default.
- W2354862223 title "Effects of levofloxacin on small RNA expression in Staphylococcus aureus" @default.
- W2354862223 hasPublicationYear "2012" @default.
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