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- W2354865986 abstract "Objective To investigate the expression of metastin and matrix metailoproteinase(MMP-9) and their relationship in cervical carcinoma.Methods The expression of metastin and MMP-9 was examined by immunohistochemical method in 10 cases of normal cervical epilhelia,15 cases of cervical carcinoma in situ(CIN),52 cases of squamous celI carcinoma of cervix(SCC).The relationship between those expression outcomes and the characteristics of clinical pathology of cervical carcinoma was analyzed statistically.Results It was found that the positive rate of metastin expression in SCC group was significantly less than CIN and normal cervix epithelial tissue group(P0.05),Loss of metastin expression was correlated with clinical stage and lymph node metastasis of SCC(P0.05),but was not correlated with age of patients and histogical grade of SCC.The positive rate of MMP-9 expression in SCC and CIN group was significantly higher than normal cervix epithelial tissue group (P0.05),High expression of MMP-9 was correlated with clinical stage and lymph node metastasis of SCC(P0.05), but was not correlated with age of patients and histogical grade of SCC.The expression of metastin is negatively correlated with MMP-9 in SCC( r = -0.428,P0.05).Conclusion This data indicated that metastin and MMP-9 expressions may be correlated with the infiltration and metastases of SCC, negative correlation of metastin and MMP-9 indicated that they may have some interaction." @default.
- W2354865986 created "2016-06-24" @default.
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- W2354865986 date "2008-01-01" @default.
- W2354865986 modified "2023-09-24" @default.
- W2354865986 title "Expression of Metastin,MMP-9 Protein and Relation in CervicaI Carcinoma" @default.
- W2354865986 hasPublicationYear "2008" @default.
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