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- W2354874857 abstract "To analyze the role of P16 gene mutation in cervical carcinoma genesis and mechanism of P16 gene mutation.The exon 2 and exon l of P16 gene was amplified by polymerase chain reaction respectivly.The products were analyzed by CDGE(constant denatured gel electrophoresis in Dcode TM apparatus)and 1 8 g/dl agarose get seperately.There are total 8 deletion mutational cases and 4 point mutations from 29 clinical specimens.The mutation rate is about 41%,and 1 of 4 exon 1 deletion mutations is uncomplete deletion mutation,which has an amplified DNA band less 343 bp.Mutation of P16 gene has played an important role in cervical carcinoma genesis.becaucse its exons own“CG”DNA repetitive sequence,P16 gene is apt to lose part of the sequence leading to mutation,so the mechanism of the mutation is that recombination and rearragement of the “CG”repetitive sequence lead to uncomplete DNA deletion.It is the reason that the rate of deletion mutation is higher than that of point mutation." @default.
- W2354874857 created "2016-06-24" @default.
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- W2354874857 date "1999-01-01" @default.
- W2354874857 modified "2023-09-28" @default.
- W2354874857 title "Mutation analysis of P16 gene in cervical carcinoma" @default.
- W2354874857 hasPublicationYear "1999" @default.
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