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- W2354886082 abstract "Objective:The objective of the current study was to determine the optimum ultrasonic extraction conditions for hypericin from H.perforatum.Method:The optimum conditions were evaluated with 2-level fractional factorial design and optimized using response surface methodology.Result:High yields of hypericin were observed from H.perforatum by ultrasonic extraction technology.The extraction time,acetone concentration and the ratio of solvent to material were the most significant parameters on hypericin extraction as evaluated through FFD.The extraction conditions were further investigated with central composite design.The results showed that the optimal parameters for this method were:extraction time of 36.15 min,acetone concentration of 68.14(Vol) of acetone/ethanol solvent,and ratio of solvent to material of 11.87 mL·g-1.Under the optimized condition,the maximum productivity of hypericin was 1.44%.The yield of hypericin under the optimized extraction conditions was greater than that obtained from conventional solvent extraction.Conclusion:The present study demonstrates that ultrasonic is a great efficient tool for the fast extraction of hypericin from H.perforatum" @default.
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- W2354886082 date "2011-01-01" @default.
- W2354886082 modified "2023-09-26" @default.
- W2354886082 title "Optimization of Ultrasonic Extraction of Hypericin in Hypericum perforatum by Response Surface Methodology" @default.
- W2354886082 hasPublicationYear "2011" @default.
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