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- W2354894653 abstract "Objective To study the expression of thymidine phosphorylase(TP) in colorectal cancer. Method TP protein and mRNA level were measured in 14 primary colorectal tumors and adjacent uninvolved tissues with ELISA and real-time RT-PCR. Results Both in mRNA and protein level, TP expression in tumors were much higher compared with the corresponding normal tissues. The level of TP protein and mRNA in tumors were 7. 82 ± 4. 31ng/μgTPO and 1. 66 ± 0. 766, respectively, those in nor-mal tissues were 5. 03 ± 2. 48 ng/μgTPO and 1. 05 ± 0. 60 > respectively. The level of mRNA were correlated with that of protein (r= 0. 81). Conclusion This result suggests that the expression of TP in tumors are high and offers a strategy for optimizing the use of 5-FU-based chemotherapy." @default.
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- W2354894653 date "2004-01-01" @default.
- W2354894653 modified "2023-09-27" @default.
- W2354894653 title "Thymidine phosphorylase expression in colorectal cancer" @default.
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