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- W2354903485 abstract "Objective To explore brain lesions in early stage of late-life depression by analyzing signal intensity abnormalities in gray matter and white matter in first-episode,medication-naive late-life depressive patients.Methods 15 first-episode,medication-naive late-life depressive patients and 15 healthy controls matched in gender,age and educational level were scaned with MRI.The data were pretreated using SPM2 software,then the T1 images of gray matter and white matter were analyzed with voxel-based morphometry to compare the MRI signal intensity.Results Compared with healthy controls,late-life depressive patients showed gray matter hypointensity in bilateral superior frontal gyrus,bilateral midfrontal gyrus,bilateral medial frontal gyrus(voxel size=5 094,t=4.31),right parietal lobe(voxel size=608,t=4.16),left cuneus(voxel size=424,t=3.19),left hippocampi(voxel size=222,t=2.90)(P0.01).Gray matter hyperintensity were found in right cingulate(voxel size=325,t=3.49) and left posterior lobe(voxel size=590,t=2.75)(P0.01);Regions of white matter hyperintensity were located in right cingulum(voxel size=1 426,t=4.23)(P0.01).Conclusion Circumscribed cortex-subcortex lesions,in which prefrontal lobe and left cingulate involved are present in early stage of late-life depression.Cerebral vascular lesion may play a role in the pathomechanism of late-life depression." @default.
- W2354903485 created "2016-06-24" @default.
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- W2354903485 date "2011-01-01" @default.
- W2354903485 modified "2023-09-23" @default.
- W2354903485 title "Abnormality of cerebral MRI signal in first-episode,medication-naive late-life depressive patients" @default.
- W2354903485 hasPublicationYear "2011" @default.
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