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- W2354906314 abstract "Objective To investigate the mechanism of ωo-3 polyunsaturated fatty acids in senile dementia. Methods The normal 15 months old Wistar rats were randomly divided into the normal control, model group and ω-3 polyunsaturated fatty acids group [EPA 2.5 g/(kg · d) by intragastric administration for 6 weeks]. The escape latency time and mistaken times were evaluated by using the step down test. The content of malondialdehyde (MDA) and superoxide dismutase (SOD) of the hippicampus tissue in rats were detected. Results Compared with the model group, ωo 3 polyunsaturated fatty acids group had lingeringly latency [(230.88 ±29.35)s vs. (189.26±31.42)s] (P0.01) and less error times [(7.3±2.2)times vs. (9.6±2.2)times](P 0.05). At the same time, ω-3 polyunsaturated fatty acids increased SOD [(70.19±12.85)U/mg prot vs. (50.47 ± 14.99)U/mg prot] and down regulated MDA of the hippicampus in rats [(7.77 ±1.57)nmol/mg prot vs. (9.39±1.44)nmol/mg prot] (P0.05). Conclusions ω-3 polyunsaturated fatty acids could improve learning- memory function in rats and protect cerebral tissue against free radical. Also provides the experimental base of treatment with senile dementia." @default.
- W2354906314 created "2016-06-24" @default.
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- W2354906314 date "2009-01-01" @default.
- W2354906314 modified "2023-09-25" @default.
- W2354906314 title "Effects of ω-3 Polyunsaturated Fatty Acids on the Ability of Learning and Memory,MDA and SOD of the Hippicampus Tissue in Rats with Senile Dementia" @default.
- W2354906314 hasPublicationYear "2009" @default.
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