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- W2354919560 abstract "Background:Severe acute pancreatitis(SAP) is one of the common acute abdominal pain,the pathogenesis is still not fully clear.Study on relationship between autophagy and inflammation in SAP is rare.Aims:To investigate the synergic effect of autophagy inhibitor 3-MA and NF-κB inhibitor PDTC on acute necrotizing pancreatitis(ANP) in rats. Methods:Ninety SD rats were randomized into sham operation group(SO group),ANP group,3-MA group,PDTC group and 3-MA + PDTC group.ANP was induced in rats by retrograde injection of 5%sodium taurocholate into pancreaticobiliary duct.Rats were sacrificed at 3,6 and 12 hours after establishment of ANP,respectively.Serum level of amylase(AMY) was determined by automatic biochemistry analyzer,interleukin(IL)-1βwas measured by ELISA. Pancreatic histopathological changes were observed by HE staining.Expressions of Bechn-1 and NF-κB in pancreas were detected by immunohistochemistry and Western blotting.Results:Compared with SO group,serum levels of AMY and IL- 1β,pancreatic pathological changes,expressions of Beclin-1 and NF-κB in ANP group were increased in a time-dependent manner(P0.05).At 6~(th),12~(th) hour,serum levels of AMY and IL-1β,pancreatic pathological changes and expressions of Beclin-1 and NF-κB in 3-MA group and PDTC group were significantly decreased than those in ANP group(P0.05). Moreover,serum levels of AMY and IL-1βwere significantly decreased in 3-MA + PDTC group than those in 3-MA group or PDTC group(P0.05).Pathological injury and expressions of Beclin-1 and NF-κB were significantly decreased at 12~(th) hour(P0.05).Conclusions:Autophagy inhibitor 3-MA and NF-κB inhibitor PDTC exert synergic effect on ANP in rats by blocking autophagy activation and inflammatory cascade reaction in pancreatic injury." @default.
- W2354919560 created "2016-06-24" @default.
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- W2354919560 date "2013-01-01" @default.
- W2354919560 modified "2023-09-25" @default.
- W2354919560 title "Synergic Effect of 3-MA Combined with PDTC on Acute Necrotizing Pancreatitis in Rats" @default.
- W2354919560 hasPublicationYear "2013" @default.
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