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- W2354928670 abstract "Objective To develop a scoring system for differential diagnosis of benign and malignant pancreatic lesions and to evaluate its diagnostic efficiency.Methods We retrospectively analyzed the medical records of patients with pancreatic lesions(with pathologically confirmed diagnosis);the patients were treated in Changhai Hospital from November 2008to May2013.A differential diagnosis model was created using multiple logistic regression analysis.A scoring system for differential diagnosis of benign and malignant pancreatic lesions was established based on each regression coefficient,and then was externally validated.The differential diagnosis efficiency of the scoring system was assessed by its consistency,differential ability and accuracy.Results A total of 1 000eligible participants were included in our research.The scoring system,which was scored from 0to 14points,comprised 4variables:age,anorexia,diabetes history and serum CA19-9.The system had good consistency(P=0.13),agood differential ability(area under the receiver operating characteristic[ROC]curve=0.82,95%confidence interval[CI]:0.79-0.86,P0.001).When score 2 was used as the predictive cut-off value,the sensitivity,specificity,accuracy,positive predictive value,negative predictive value,positive likelihood ratio and negative likelihood ratio were 81.46%,66.88%,77.86%,88.26%,54.12%,2.46,and 0.28,respectively.The risk(88.26%)ofmalignant pancreatic lesions in patients with high-risk scores(2)was significantly higher than that(45.88%)in patients with low-scores(≤2)(P0.001).External validation results showed the scoring system had good differential ability(area under the ROC curve=0.81,95%CI:0.76-0.86,P0.001)and consistency(P=0.716).Conclusion The prediction model and its scoring system is of great value for risk stratification of benign and malignant pancreatic lesions,which may be serve as an initial evidence for differential diagnosis of pancreatic lesions." @default.
- W2354928670 created "2016-06-24" @default.
- W2354928670 creator A5061116773 @default.
- W2354928670 date "2014-01-01" @default.
- W2354928670 modified "2023-09-24" @default.
- W2354928670 title "A scoring system for differential diagnosis of benign and malignant pancreatic lesions:establishment and validation" @default.
- W2354928670 hasPublicationYear "2014" @default.
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