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- W2354954298 abstract "Objective To investigate the features of hippocampal atrophy (HA) by MRI in mild moderate AD (Alzheimer′s disease) patients and its values as an early diagnostic marker for AD. Methods There were 34 mild moderate AD patients and 30 normal controls in the study, and the differences of the hippocampal volume by MRI between the mild moderate patients and the controls were studied. By ROC (receiver operating characteristic curve) method, the cut off point of the hippocampal volume was calculated as an early diagnostic marker for AD and its values were estimated.Results The volume of hippocampus of the AD patients was significantly less than that of the controls ( P 0.01), 17% of the mild AD patients was in the range of the control, and so did 12% of the mild moderate AD; The relative mean hippocampal volume of AD to the control were as follows: in the mild group the mean volume of hippocampus = the mean volume of hippocampus of control -1.8 standard deviation and in the moderate AD group, the volume of hippocampus = the volume of hippocampus of controls -3.2 standard deviations. The hippocampal volume in both of the AD and the control groups decreased with age, but the speed of decreasing of AD was faster ( P 0.05). The best cut off point of hippocampal volume, as a diagnostic marker, was 2.7 cm 3 with the sensitivity of 88% and specificity of 93%.Conclusion MRI based HA could effectively differentiate the mild moderate AD patients from the normal subjects. HA detected by MRI could be regarded as a valuable marker in making clinical diagnosis of AD (especially in its early stage)." @default.
- W2354954298 created "2016-06-24" @default.
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- W2354954298 date "2000-01-01" @default.
- W2354954298 modified "2023-09-24" @default.
- W2354954298 title "Study of hippocampal atrophy in mild and moderate Alzheimer′s disease by magnetic resonance imaging" @default.
- W2354954298 hasPublicationYear "2000" @default.
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