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- W2354975463 abstract "Aim To explore the changes of aortic morphology and expression of miRNA-195 in aorta of spontaneously hypertensive rats( SHR),and the effect of benazepril on them. Methods 8-week-old male SHRs were randomly divided into SHR benazepril treatment group( SB group,benazepril 10 mg /( kg·d),n = 8) and SHR control group( SC group,n =8),and Wistar rats of the same age served as control were also randomly divided into benazepril treatment group( WB group,benazepril 10 mg /( kg·d),n = 8) and control group( WC group,n = 8). After 8 weeks treatment, tail arterial blood pressures of rats were measured,aortic morphology were detected by hemotoxylin and eosin staining,and expression level of mi RNA-195 in aorta of rats were detected by qRT-PCR,and expression level of TGF-β1,Smad3,COL-Ⅰ and COL-Ⅲ proteins were detected by Western blot. Results After 8 weeks of medication,the tail arterial systolic blood pressure and diatolic blood pressure of rats in SB group was lower than that in SC group( P 0. 01),but was higher than that in WB group( P 0. 01). The expression of miRNA-195 in aorta of rats in SB group was higher than that in SC group,WB group and WC group( P 0. 05 or P 0. 01). The expression levels of TGF-β1 and Smad3 in aorta of rats in SB group were lower those that in SC group( P 0. 05),but higher than those in WB group( P 0. 01),and the expression of COL-Ⅰ and COL-Ⅲ protein showed a similar change( P 0. 05 or P 0. 01). Aortic morphology of rats in SB group was improved compared with SC group,but did not reach the level of that in WC group. Conclusions Treatment with Benazepril can ameliorate the aortic morphology of SHR,and miRNA-195 may play a role in this process, by inhibiting TGF-β1 / Smad3 signaling pathway." @default.
- W2354975463 created "2016-06-24" @default.
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- W2354975463 date "2014-01-01" @default.
- W2354975463 modified "2023-09-24" @default.
- W2354975463 title "miRNA-195,Benazepril and Aortic Remodeling in Spontaneously Hypertensive Rats" @default.
- W2354975463 hasPublicationYear "2014" @default.
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