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- W2354976270 abstract "Objective To investigate the effect of HBx siRNA on MMP-9 gene expression of HepG2.2.15 cells.Methods Specific siRNA against HBx was transfected into HepG2.2.15 cell.The mRNA expression levels of HBx and MMP-9 were assayed by Real-time PCR.The protein expression levels of MMP-9 were evaluated by Western blot.Results Results Real-time PCR testing results showed that the expressions of HBx mRNA were 121.13±8.72,83.17±7.93,56.33±6.17 in experimental group cells after transfection of 24h,48h,72h,compared with control group cells(137.28 ±12.33),the difference had statistical significance(P0.01).The expression of MMP-9 mRNA was 83.27±6.17,69.37±8.26,58.18±4.77 after transfection of 24h,48h,72h,compared with control group cells(131.27±16.28),the difference had statistical significance(P0.01).Western blot testing results showed that the expressions of MMP-9 protein were 0.357±0.025,0.218±0.051 in experimental group cells after transfection of 24h,48h,compared with control group cells(0.475±0.073),the difference had statistical significance(P0.05).Conclusion Our research demonstrates that inhibition of the expression of HBx gene by RNA interference could down-regulated MMP-9 gene which is related to tumor at mRNA and protein level." @default.
- W2354976270 created "2016-06-24" @default.
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- W2354976270 date "2014-01-01" @default.
- W2354976270 modified "2023-09-23" @default.
- W2354976270 title "The effect of HBx siRNA on MMP-9 gene expression of human hepatocellular carcinoma cell HepG2.2.15" @default.
- W2354976270 hasPublicationYear "2014" @default.
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